1. Immunology/Inflammation
  2. PGE synthase
  3. Bismuth Subsalicylate

Bismuth Subsalicylate (Synonyms: Bismuth oxysalicylate; Bismuth(III) salicylate basic)

Cat. No.: HY-B0550
Handling Instructions

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al.

For research use only. We do not sell to patients.

Bismuth Subsalicylate Chemical Structure

Bismuth Subsalicylate Chemical Structure

CAS No. : 14882-18-9

Size Price Stock Quantity
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g USD 108 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Description

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo[1]. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al[1][2].

In Vivo

In the gastrointestinal tract, Bismuth Subsalicylate can be converted to salicylic acid and insoluble bismuth salts. Salicylic acid reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2[1].
Bismuth Subsalicylate (oral gavage; 100 mg/kg-350 mg/kg) significantly decreases castor oil-induced movement of a charcoal test meal along the small intestine of the mouse and rat and also decreases both the fecal output (dry or wet weight) and the frequency of diarrhea in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

362.09

Formula

C₇H₅BiO₄

CAS No.

14882-18-9

SMILES

O=C1O[Bi](O)OC2=CC=CC=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.76 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7617 mL 13.8087 mL 27.6174 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Bismuth SubsalicylateBismuth oxysalicylate Bismuth(III) salicylate basicPGE synthaseProstaglandin E synthaseheartburnacid reflux,?indigestion,?diarrhoeasickantacidnausea,?salicylateinflammationInhibitorinhibitorinhibit

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Bismuth Subsalicylate
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