1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor
  3. Calcitonin Gene Related Peptide (CGRP) (83-119), rat

Calcitonin Gene Related Peptide (CGRP) (83-119), rat 

Cat. No.: HY-P1462
Handling Instructions

Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

For research use only. We do not sell to patients.

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Calcitonin Gene Related Peptide (CGRP) (83-119), rat Chemical Structure

Calcitonin Gene Related Peptide (CGRP) (83-119), rat Chemical Structure

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Description

Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

IC50 & Target

CRLR[3]

In Vitro

Calcitonin Gene Related Peptide (CGRP) (83-119), rat belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR)[1]. Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGRP is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pmol) induces a rapidly developing (5-15 min) and long-lasting (6 h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pmol) potentiates the oedema induced by co-injected substance P (3.7 nmol)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3806.30

Formula

C₁₆₂H₂₆₂N₅₀O₅₂S₂

Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[3]

Rat[3]
Male Wistar rats, weighing 150-250 g, are used throughout this study. As soon as the righting reflex is lost, the initial (t = 0) measurement of cheek thickness (in mm) is made with digital calipers, the intra-oral injection given and then cheek thickness measured again at 5, 15 and 30 min, 1, 2, 3, 4, 6 and 24 h, following agonists (CGRP, etc) or saline injections. Cheek thickness in λ-carrageenan (CG)-injected animals is measured at 0, 15, 30 min, 1, 2, 3, 4, 5, 6 and 24 h. Paw thickness (in mm) is obtained similarly, using the calipers at the time points indicated for cheek oedema, with the only difference being that the animals are not anesthetized for local (intraplantar) injections[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Calcitonin Gene Related Peptide (CGRP) (83-119), ratCGRP ReceptorCalcitonin gene-related peptide receptorInhibitorinhibitorinhibit

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Product Name:
Calcitonin Gene Related Peptide (CGRP) (83-119), rat
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HY-P1462
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