1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA 

Cat. No.: HY-P1462A Purity: 96.21%
Handling Instructions

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA Chemical Structure

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA Chemical Structure

Size Price Stock Quantity
500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Other Forms of Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).

IC50 & Target

CRLR[1].

In Vitro

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR)[1]. Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches[2].

In Vivo

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA) is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pM) induces a rapidly developing (5-15 min) and long-lasting (6 h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pM) potentiates the oedema induced by co-injected substance P (3.7 nM)[3].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2551 mL 1.2754 mL 2.5508 mL
5 mM 0.0510 mL 0.2551 mL 0.5102 mL
10 mM 0.0255 mL 0.1275 mL 0.2551 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Rats[3]
Male Wistar rats, weighing 150-250 g, are used throughout this study. As soon as the righting reflex is lost, the initial (t=0) measurement of cheek thickness (in mm) is made with digital calipers, the intra-oral injection given and then cheek thickness measured again at 5, 15 and 30 min, 1, 2, 3, 4, 6 and 24 h, following agonists ( Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), etc) or saline injections. Cheek thickness in λ-carrageenan (CG)-injected animals is measured at 0, 15, 30 min, 1, 2, 3, 4, 5, 6 and 24 h. Paw thickness (in mm) is obtained similarly, using the calipers at the time points indicated for cheek oedema, with the only difference being that the animals are not anesthetized for local (intraplantar) injections[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

3920.32

Formula

C₁₆₂H₂₆₂N₅₀O₅₂S₂.C₂HF₃O₂

Storage

polypeptide, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA
Cat. No.:
HY-P1462A
Quantity:

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA

Cat. No.: HY-P1462A