1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Sodium Channel
    GABA Receptor

Cenobamate (Synonyms: YKP3089)

Cat. No.: HY-17607 Purity: 99.50% ee.: 99.74%
Handling Instructions

Cenobamate, a sodium channel blocker, enhances GABAergic transmission and has the potential to be a versatile CNS drug.

For research use only. We do not sell to patients.

Cenobamate Chemical Structure

Cenobamate Chemical Structure

CAS No. : 913088-80-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Cenobamate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cenobamate, a sodium channel blocker, enhances GABAergic transmission and has the potential to be a versatile CNS drug.

IC50 & Target

Sodium channel, GABA receptor[1].

In Vivo

Cenobamate (YKP3089) protects against MES induced seizures in mice with an ED50 of 9.8 mg/kg i.p., and in rats with an ED50 of 1.9 mg/kg p.o. In the sc Met seizures model, Cenobamate given ip inhibited the clonic seizures in mice and rats, with ED50 values of 28.5 and 13.6 mg/kg, respectively. Cenobamate is also effective against seizure induced by picrotoxin with an ED50 of 34.5 mg/kg in mice. Cenobamate is effective in reducing significantly the expression of stage 5 seizures in the hippocampal kindled rat (ED50=16.4 mg/kg). Cenobamate is effective in the mouse 6 Hz psychomotor seizure model at 22, 32 and 44 mA, with ED50 values of 11.0, 17.9 and 16.5 mg/kg, respectively. Cenobamate also protects against lithiumpilocarpine-induced intractable seizures in rats (ip) (ED50=7.0 mg/kg)[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 126 mg/mL (470.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7359 mL 18.6797 mL 37.3594 mL
5 mM 0.7472 mL 3.7359 mL 7.4719 mL
10 mM 0.3736 mL 1.8680 mL 3.7359 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

267.67

Formula

C₁₀H₁₀ClN₅O₂

CAS No.

913088-80-9

SMILES

NC(O[[email protected]](C1=CC=CC=C1Cl)CN2N=CN=N2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cenobamate
Cat. No.:
HY-17607
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Cenobamate

Cat. No.: HY-17607