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Product Name: | 4'-Demethylepipodophyllotoxin | |
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CAS No.: | 6559-91-7 | |
Cat. No.: | HY-17435 | |
MWt: | 400.38 | |
Formula: | C21H20O8 | |
Purity : | >98% | |
Solubility: | DMSO : 100 mg/mL (ultrasonic) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.
In Vitro:4'-Demethylepipodophyllotoxin decreases the XooFtsZ'GTPase activity, and shows bacteriostatic effect (EC50 = 38.7 μg/mL) against Xanthomonas oryzae pv. oryzae (Xoo)[3]. 4'-Demethylepipodophyllotoxin shows cytotoxicity activity against tumor cells, with EC50 of 0.31, 0.32, 0.37, 0.43 μM for HL-60, K-562, HepG2, KB cells[1]. In Vivo:4'-Demethylepipodophyllotoxin (1 µg/mL, 200 µL, topical application, 24 weeks) reduces the tumor incidence, tumor volume, and the conversion efficiency of papillomas to squamous cell carcinomas in DMBA/TPA-induced mouse skin carcinogenesis model[1]. |
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