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Ansamitocin P-3 Data Sheet
| Product Name: | Ansamitocin P-3 |
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|---|---|---|
| CAS No.: | 66584-72-3 | |
| Cat. No.: | HY-15739 | |
| MWt: | 635.14482 | |
| Formula: | C32H43ClN2O9 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 100 mg/mL (157.45 mM) | |
| Mechanisms: | Target: Cancer Infection | |
| Biological Activity: | ||
| Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic. IC50 & Target: Microtubule[1] In Vitro: Ansamitocin P-3 (Antibiotic C 15003P3) potently inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture with a half-maximal inhibitory concentration of 20±3, 50±0.5, 140±17, and 150±1.1 pM, respectively. Further, Ansamitocin P3 is found to bind to purified tubulin in vitro with a dissociation constant (Kd) of 1.3±0.7 µM. The binding of Ansamitocin P3 induces conformational changes in tubulin. Ansamitocin P3 inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture in a concentration dependent manner. Flow cytometric analysis of PI-stained cells suggests that Ansamitocin P3 inhibits the cell cycle progression of MCF-7 cells in G2/M phase. For example, 26, 50 and 70% of the cells are found to be in G2/M phase in the absence and presence of 50 and 100 pM Ansamitocin P3, respectively[2]. | ||
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