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Product Name: | Cabazitaxel | |
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CAS No.: | 183133-96-2 | |
Cat. No.: | HY-15459 | |
MWt: | 835.93 | |
Formula: | C45H57NO14 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 100 mg/mL (119.63 mM) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. In Vitro: The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%[1]. In Vivo: Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group[1]. |
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