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Capadenoson Data Sheet

Product Name: Capadenoson
CAS No.: 544417-40-5
Cat. No.: HY-14917
MWt: 520.03
Formula: C25H18ClN5O2S2
Purity : >98%
Solubility: DMSO : ≥ 50 mg/mL (96.15 mM); H2O : < 0.1 mg/mL (insoluble)
Mechanisms: Target: Cardiovascular Disease
Biological Activity:
Capadenoson is a selective agonist of adenosine-A1 receptor. IC50 & Target: Adenosine A1 receptor[1] In Vitro: To further elucidate the pharmacological properties of Capadenson, GTP shift assays are performed with the standard full A1-agonist CCPA and the A1-antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). CCPA shows a Ki value of 4.2 nM in the binding assay on rat cortical brain membranes. In the presence of 1 mM GTP this Ki value shifts to a value of 64 nM. Therefore the GTP shift for CCPA is 15. DPCPX shows a GTP shift of 1 with virtually identical Ki values in the absence and presence of GTP. Capadenson shows a Ki value of 24 nM in the binding assay. In the presence of 1 mM GTP this Ki value shifts to a value of 116 nM resulting in a GTP shift of 5 for Capadenoson[1]. In Vivo: In the in vivo experiments, Wistar rats and SHR are pre-treated with Capadenoson at a concentration of 0.15 mg/kg for 5 days. On day 5, a stress test (physical restraint) is performed for 2 hours. The plasma concentration of Capadenoson measured 3 hours after drug intake remains constant in the 5 days prior to the restraint stress test and averaged 7.63 µg/L on day 4 and 5, respectively[1].

Caution: Not fully tested. For research purposes only

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