Network Version
Dioxybenzone Data Sheet
| Product Name: | Dioxybenzone |
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|---|---|---|
| CAS No.: | 131-53-3 | |
| Cat. No.: | HY-B0966 | |
| MWt: | 244.24 | |
| Formula: | C14H12O4 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 100 mg/mL;H<sub>2</sub>O : < 0.1 mg/mL | |
| Mechanisms: | Target: Cancer Inflammation/Immunology | |
| Biological Activity: | ||
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Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study[1][2][3].
In Vitro:Dioxybenzone (0.1-1 μM, 24-72 h) exhibits estrogenic disrupting effect via increasing the mRNA expressions and production of the growth factors responsible for epithelial proliferation, including Fgfs and Igf-1 in human endometrial stromal cells (HESCs)[2]. Dioxybenzone (0.1-1 μM, 24-72 h) up-regulates the mRNA expressions of inflammatory cytokines especially IL-1β in HESCs[2]. Dioxybenzone (20-600 μM, 24 h) chlorination decreases its UV absorbance and generates cytotoxic product(s) in human diploid fibroblasts (HDFs) [3]. In Vivo:Dioxybenzone (0.0025% in drinking water; one week prior to tumor initiation and lasts 2 weeks) exhibits a significant chemopreventive activity against mouse skin carcinogenesis in NOR-1-induced mice model[1]. Dioxybenzone (20-100 mg/kg; i.p.; daily for 3 days) increases mRNA expressions of estrogen signaling and inflammation target genes in mice uterus[2]. Dioxybenzone (20-100 mg/kg; i.p.; daily for 3 days) significantly induces transcriptome aberration involved in cancer, reproductive system disease and inflammatory disease[2]. |
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