Network Version
Entecavir monohydrate Data Sheet
| Product Name: | Entecavir monohydrate |
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| CAS No.: | 209216-23-9 | |
| Cat. No.: | HY-13623A | |
| MWt: | 295.29 | |
| Formula: | C12H17N5O4 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 50 mg/mL (169.33 mM); H2O : 2.8 mg/mL (9.48 mM; Need ultrasonic and warming) | |
| Mechanisms: | Target: Cancer Infection | |
| Biological Activity: | ||
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Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
IC50 & Target:EC50：3.75 nM (anti-HBV, HepG2 cell)[1]
In Vitro: Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir monohydrate is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2]. In Vivo: Daily oral treatment with Entecavir monohydrate at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3]. |
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