Network Version
Product Name: | Entecavir | |
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CAS No.: | 142217-69-4 | |
Cat. No.: | HY-13623 | |
MWt: | 277.28 | |
Formula: | C12H15N5O3 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 44 mg/mL (158.68 mM) | |
Mechanisms: | Target: Cancer Infection | |
Biological Activity: | ||
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. IC50 & Target:EC50: 3.75 nM (anti-HBV, HepG2 cell)[2] In Vitro: BMS-200475 has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2]. In Vivo: Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3]. |
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