Medchemexpress

Network Version

Entecavir Data Sheet

Product Name: Entecavir
CAS No.: 142217-69-4
Cat. No.: HY-13623
MWt: 277.28
Formula: C12H15N5O3
Purity : >98%
Solubility: DMSO : ≥ 44 mg/mL (158.68 mM)
Mechanisms: Target: Cancer Infection
Biological Activity:
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. IC50 & Target:EC50: 3.75 nM (anti-HBV, HepG2 cell)[2] In Vitro: BMS-200475 has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2]. In Vivo: Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3].

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

www.medchemexpress.com

1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com

Keywords: buy Entecavir | Entecavir Supplier | purchase Entecavir | Entecavir cost | Entecavir manufacturer | order Entecavir | Entecavir distributor | Entecavir structure buy 142217-69-4 | 142217-69-4 Supplier | purchase 142217-69-4 | 142217-69-4 cost | 142217-69-4 manufacturer | order 142217-69-4 | 142217-69-4 distributor | 142217-69-4 structure