Network Version
Product Name: | Epothilone B | |
---|---|---|
CAS No.: | 152044-54-7 | |
Cat. No.: | HY-17029 | |
MWt: | 507.68 | |
Formula: | C27H41NO6S | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 125 mg/mL (246.22 mM) | |
Mechanisms: | Target: Cancer Infection | |
Biological Activity: | ||
Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation. IC50 & Target: EC0.01: 1.8 μM (Microtubule/Tubulin)[1] In Vitro: Epothilone B inhibits HCT116 cells with IC50 of 0.8 nM in HCT-116 cell line cytotoxicity assay[1]. Epothilone B (Patupilone) is a microtubule (MT) targeting agent. As shown by MTT cell proliferation assay, after 72 h of treatment Epothilone B efficiently inhibits cell growth with an IC50 of 6 nM, while concentrations ≤1 nM are not cytotoxic. Epothilone B significantly inhibits transwell cell migration at the non-cytotoxic concentration of 1 nM, and the effect is more evident at 10 nM[2]. Epothilone B (Patupilone) is a novel, non-taxane-related and nonneurotoxic microtubule-stabilizing agent in human medulloblastoma cell lines. Epothilone B reduces the proliferative activity in the D341 cell line, with an IC50 of 0.53 nM; in the D425Med cell line, with an IC50 of 0.37 nM; and in the DAOY cell line, with an IC50 of 0.19 nM. In the D341Med cell line, the effect of Epothilone B on clonogenic survival is at dose range of Epothilone B similar to the level of proliferative activity and viability (IC50, 0.50-0.75 nM). However, the clonogenicity of D425Med and DAOY cells is already strongly reduced at a 10-fold lower concentration of Epothilone B (IC50, 30 pM). These results overall demonstrate that Epothilone B is highly potent against different medulloblastoma cell lines[3]. In Vivo: Treatment with Epothilone B (Patupilone) or ionizing radiation alone results in a partial tumor growth suppression over 10 days, whereas combined treatment exerts a strong supra-additive tumor growth control, with complete tumor regression in the follow-up period (P<0.005, for ionizing radiation or Epothilone B alone vs combined treatment)[3]. |
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com
Keywords: buy Epothilone B | Epothilone B Supplier | purchase Epothilone B | Epothilone B cost | Epothilone B manufacturer | order Epothilone B | Epothilone B distributor | Epothilone B structure buy 152044-54-7 | 152044-54-7 Supplier | purchase 152044-54-7 | 152044-54-7 cost | 152044-54-7 manufacturer | order 152044-54-7 | 152044-54-7 distributor | 152044-54-7 structure