Network Version
Product Name: | Ilomastat | |
---|---|---|
CAS No.: | 142880-36-2 | |
Cat. No.: | HY-15768 | |
MWt: | 388.46 | |
Formula: | C20H28N4O4 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 47 mg/mL (120.99 mM) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1). In Vitro: Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis of 0.4 nM, 20 nM, 20 nM, resepctively[1]. Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing[4]. In Vivo: Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals[2]. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting[3]. |
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com
Keywords: buy Ilomastat | Ilomastat Supplier | purchase Ilomastat | Ilomastat cost | Ilomastat manufacturer | order Ilomastat | Ilomastat distributor | Ilomastat structure buy 142880-36-2 | 142880-36-2 Supplier | purchase 142880-36-2 | 142880-36-2 cost | 142880-36-2 manufacturer | order 142880-36-2 | 142880-36-2 distributor | 142880-36-2 structure