Network Version
GSK2606414 Data Sheet
| Product Name: | GSK2606414 |
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|---|---|---|
| CAS No.: | 1337531-36-8 | |
| Cat. No.: | HY-18072 | |
| MWt: | 451.44 | |
| Formula: | C24H20F3N5O | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 100 mg/mL (221.51 mM) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM. IC50 & Target: IC50: 0.4 nM (PERK) In Vitro: GSK2606414 inhibits PERK activation in cells[1]. In Vivo: GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice[1]. | ||
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