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IOX2 Data Sheet

Product Name: IOX2
CAS No.: 931398-72-0
Cat. No.: HY-15468
MWt: 352.34
Formula: C19H16N2O5
Purity : >98%
Solubility: DMSO : 25 mg/mL (ultrasonic)
Mechanisms: Target: Cancer
Biological Activity:
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases[1][2]. IC50 & Target:IC50: 22 nM (PHD2)[2] In Vitro:IOX2 (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3[1].
IOX2 also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction[1].
IOX2 (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition[2].
In Vivo:IOX2 (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice[1].

Caution: Not fully tested. For research purposes only

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