Network Version
Product Name: | IOX2 | |
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CAS No.: | 931398-72-0 | |
Cat. No.: | HY-15468 | |
MWt: | 352.34 | |
Formula: | C19H16N2O5 | |
Purity : | >98% | |
Solubility: | DMSO : 25 mg/mL (ultrasonic) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases[1][2].
IC50 & Target:IC50: 22 nM (PHD2)[2]
In Vitro:IOX2 (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3[1]. IOX2 also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction[1]. IOX2 (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition[2]. In Vivo:IOX2 (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice[1]. |
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