Network Version
Product Name: | ITE | |
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CAS No.: | 448906-42-1 | |
Cat. No.: | HY-19317 | |
MWt: | 286.31 | |
Formula: | C14H10N2O3S | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 41 mg/mL (143.20 mM) | |
Mechanisms: | ||
Biological Activity: | ||
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity. IC50 & Target: Ki: 3 nM (AhR)[1] In Vitro: ITE is an endogenous agonist of AhR, binding directly to AHR, with a Ki of 3 nM[1]. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses[2]. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs[3]. In Vivo: ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice[2]. |
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