Network Version
Product Name: | Lagociclovir | |
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CAS No.: | 92562-88-4 | |
Cat. No.: | HY-14844 | |
MWt: | 269.23 | |
Formula: | C10H12FN5O3 | |
Purity : | >98% | |
Solubility: | 10 mM in DMSO | |
Mechanisms: | Target: Infection | |
Biological Activity: | ||
Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV[1].
IC50 & Target:HBV[1]
In Vitro:Lagociclovir (FLG) (6 days) shows inhibitory activity with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM against 3TC-R HBV, wt HBV, PMEA-R HBV and 3TC+PMEA-R HBV, respectively in transiently transfected Huh7 cells[1]. Lagociclovir (0-100 μM; 6 days) inhibits the replication of wild-type and drug-resistant mutants of HBV in transiently transfected Huh7 cells[1]. |
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