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MMAF hydrochloride Data Sheet
| Product Name: | MMAF hydrochloride |
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|---|---|---|
| CAS No.: | 1415246-68-2 | |
| Cat. No.: | HY-15579A | |
| MWt: | 768.42 | |
| Formula: | C39H66ClN5O8 | |
| Purity : | >98% | |
| Solubility: | DMSO : 27 mg/mL (35.14 mM; Need ultrasonic and warming); H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A[1][2][3]. IC50 & Target: IC50: 119 nM (Cytotoxicity, Karpas 299 cell), 105 nM (Cytotoxicity, H3396 cell), 257 nM (Cytotoxicity, 786-O cell), 200 nM (Cytotoxicity, Caki-1, cell)[4] In Vitro: MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[4]. In Vivo: The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively[4]. | ||
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