Network Version
Mc-MMAE Data Sheet
| Product Name: | Mc-MMAE |
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|---|---|---|
| CAS No.: | 863971-24-8 | |
| Cat. No.: | HY-15741 | |
| MWt: | 911.18 | |
| Formula: | C49H78N6O10 | |
| Purity : | >98% | |
| Solubility: | DMSO : 180 mg/mL (197.55 mM; Need ultrasonic); H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC. IC50 & Target: Tubulin, Antibody-drug conjugates (ADC)[1] In Vitro: Synthesis of maleimidocaproyl-MMAE (mc-MMAE) requires the addition of maleimidocaproic acid to a solution of MMAE in dichloromethane followed by the addition of diethyl cyanophosphonate and diisopropylethylamine[1]. | ||
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