Network Version
Merbromin Data Sheet
| Product Name: | Merbromin |
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|---|---|---|
| CAS No.: | 129-16-8 | |
| Cat. No.: | HY-B0961 | |
| MWt: | 752.67 | |
| Formula: | C20H10Br2HgNa2O6 | |
| Purity : | >98% | |
| Solubility: | DMSO : 6.67 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Others | |
| Biological Activity: | ||
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Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].
In Vitro:Merbromin (0-10 μM) affects both the KM and Kcat of 3CLpro, where the KM value increases from 9.02 μM to 14.28 μM, and the Kcat value decreases from 1.45 min to 0.63 min[1]. Merbromin with the KD for 3CLpro is 0.23 μM[1]. |
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