Network Version
Product Name: | NMS-873 | |
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CAS No.: | 1418013-75-8 | |
Cat. No.: | HY-15713 | |
MWt: | 520.67 | |
Formula: | C27H28N4O3S2 | |
Purity : | >98% | |
Solubility: | DMSO : 20.5 mg/mL (39.37 mM; Need ultrasonic and warming) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. IC50 & Target: IC50: 30 nM[1] In Vitro: NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value[1]. |
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