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NMS-873 Data Sheet

Product Name: NMS-873
CAS No.: 1418013-75-8
Cat. No.: HY-15713
MWt: 520.67
Formula: C27H28N4O3S2
Purity : >98%
Solubility: DMSO : 20.5 mg/mL (39.37 mM; Need ultrasonic and warming)
Mechanisms: Target: Cancer
Biological Activity:
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM. IC50 & Target: IC50: 30 nM[1] In Vitro: NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value[1].

Caution: Not fully tested. For research purposes only

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