Network Version
NVP-BVU972 Data Sheet
| Product Name: | NVP-BVU972 |
 |
|---|---|---|
| CAS No.: | 1185763-69-2 | |
| Cat. No.: | HY-15456 | |
| MWt: | 340.38 | |
| Formula: | C20H16N6 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (293.79 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
|
NVP-BVU972 is an selective and potent Met inhibitor, with an IC50 of 14 nM. NVP-BVU972 also exhibits good anti-proliferative activity against Met with drug-resistant mutations and inhibits phosphorylation. NVP-BVU972 can be used in study of cancer[1].
In Vitro: NVP-BVU972 (600 nM-9.6 µM; 72 h) shows good antiproliferative activity to BaF3 cells with MET mutations[1]. NVP-BVU972 (0-10 µM; 2 h) reduces TPR-MET phosphorylation in a dose-dependent manner in BaF3 TPR-MET cells[1]. |
||
1 Deer Park Dr, Suite F, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com