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Nastorazepide Data Sheet

Product Name: Nastorazepide
CAS No.: 209219-38-5
Cat. No.: HY-17617
MWt: 520.62
Formula: C29H36N4O5
Purity : >98%
Solubility: DMSO : ≥ 32 mg/mL
Mechanisms: Target: Cancer Endocrinology
Biological Activity:
Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Target:CCK-2 in vitro: Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. in vivo: Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.

Caution: Not fully tested. For research purposes only

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