Network Version
PI-3065 Data Sheet
| Product Name: | PI-3065 |
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|---|---|---|
| CAS No.: | 955977-50-1 | |
| Cat. No.: | HY-12235 | |
| MWt: | 506.64 | |
| Formula: | C27H31FN6OS | |
| Purity : | >98% | |
| Solubility: | DMSO : 25 mg/mL (49.34 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble) | |
| Mechanisms: | Target: Cancer Inflammation/Immunology | |
| Biological Activity: | ||
| PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM. IC50 & Target: IC50: 5 nM (p110δ), 910 nM (p110α), 600 nM (p110β), >10000 nM (p110γ)[1] In Vitro: PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ[1]. In Vivo: PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss[1]. | ||
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