Network Version
Paclitaxel Data Sheet
| Product Name: | Paclitaxel |
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|---|---|---|
| CAS No.: | 33069-62-4 | |
| Cat. No.: | HY-B0015 | |
| MWt: | 853.91 | |
| Formula: | C47H51NO14 | |
| Purity : | >98% | |
| Solubility: | H2O : < 0.1 mg/mL (insoluble); DMSO : 100 mg/mL (117.11 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].
IC50 & Target: IC50: 4 nM (Microtubule)
In Vitro: Paclitaxel (20 nM; 48 hours) induces programmed cell death and exists a block at the G2/M phase of the cell cycle[1]. Paclitaxel (20 nM; 48 hours) induces a consistent increase in the level of p53[1]. In Vivo: Paclitaxel (1-20 mg/kg; i.p.; 1 time/2 days for five cycles) obviously induces liver metastases at the low-Paclitaxel group with little influence on primary tumor growth[3]. |
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