Network Version
Product Name: | Podofilox | |
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CAS No.: | 518-28-5 | |
Cat. No.: | HY-15552 | |
MWt: | 414.41 | |
Formula: | C22H22O8 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 100 mg/mL (241.31 mM) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. IC50 & Target: Topoisomerase II; Microtubule/Tubulin In Vitro: Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. |
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