Network Version
R-1479 Data Sheet
| Product Name: | R-1479 |
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|---|---|---|
| CAS No.: | 478182-28-4 | |
| Cat. No.: | HY-10444 | |
| MWt: | 284.23 | |
| Formula: | C9H12N6O5 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (351.83 mM; Need ultrasonic) | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
| R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM)[1][2][3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. IC50 & Target:IC50: 1.28 μM (HCV replication)[1] In Vitro: R-1479 (R1479) inhibits HCV RNA replication with a mean IC50 value of 1.28 μM when measured as dose-dependent reduction of Renillaluciferase activity after a 72 h incubation of proliferating replicon cells. R-1479 shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM[1]. The most potent and non-cytotoxic derivative is R-1479 with an IC50 of 1.28 μM in the HCV replicon system. The triphosphate of R-1479 is prepared and shown to be an inhibitor of RNA synthesis mediated by NS5B (IC50=320 nM), the RNA polymerase encoded by HCV. R-1479 displays good activity in the replicon assay with no measurable cytotoxic or cytostatic effect[2]. | ||
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