Network Version
Idasanutlin Data Sheet
| Product Name: | Idasanutlin |
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|---|---|---|
| CAS No.: | 1229705-06-9 | |
| Cat. No.: | HY-15676 | |
| MWt: | 616.48 | |
| Formula: | C31H29Cl2F2N3O4 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 45 mg/mL | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM. IC50 & Target:IC50: 6 nM (p53-MDM2)[1] In Vitro:Idasanutlin (RG7388) inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53[1]. Idasanutlin (RG7388) (300 nM or 1.8 μM) induces apoptosis in SJSA osteosarcoma cells[2]. In Vivo:Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model[1]. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model[2]. | ||
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