Network Version
SB 525334 Data Sheet
| Product Name: | SB 525334 |
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|---|---|---|
| CAS No.: | 356559-20-1 | |
| Cat. No.: | HY-12043 | |
| MWt: | 343.42 | |
| Formula: | C21H21N5 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (291.19 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. IC50 & Target: IC50: 14.3 nM (ALK5)[1] In Vitro: SB525334 (1 μM; for 15 minutes before stimulating with 0.625 ng/ml of TGF-β1, assesses after 6 days) inhibits TGF-β1-mediated proliferation of familial idiopathic pulmonary arterial hypertension (iPAH) pulmonary artery smooth muscle cells (PASMCs) at an IC50 of 295 nM [2]. In Vivo: SB525334 (3-30 mg/kg; p.o.; daily from days 17 to 35) significantly reverses pulmonary arterial pressure in a rat model of pulmonary arterial hypertension (PAH)[2]. | ||
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