Network Version
Product Name: | TAK-715 | |
---|---|---|
CAS No.: | 303162-79-0 | |
Cat. No.: | HY-10456 | |
MWt: | 399.51 | |
Formula: | C24H21N3OS | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 100 mg/mL (250.31 mM) | |
Mechanisms: | Target: Inflammation/Immunology | |
Biological Activity: | ||
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model[1][2].
In Vitro: TAK-715 (compound 8h) inhibits LPS-stimulated release of TNF-α from THP-1 (IC50=48 nM) and has no inhibitory activity for major CYPs, including CYP3A4. TAK-715 has no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1 (IC50>10 μM of all)[1]. TAK 715 (10 μM; 1 hour) inhibits Wnt-3a-induced hDvl2 phosphorylation and the hDvl2 shift in U2OS-EFC cells[2]. TAK-715 (1 μM; pretreatment for 16 hours) dramatically suppresses Norepinephrine (NE)-stimulated induction of fibronectin, CTGF, and Snai1 expression in TGF-β1-treated HK-2 cells at both the mRNA and protein levels[3]. In Vivo: TAK-715 (compound 8h; 3-30 mg/kg; PO) significantly reduces the secondary paw volume[1]. TAK-715 (10 mg/kg; PO) has a Cmax of 0.19 μg/mL and an AUC of 1.16 μg•h/mL. |
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com
Keywords: buy TAK-715 | TAK-715 Supplier | purchase TAK-715 | TAK-715 cost | TAK-715 manufacturer | order TAK-715 | TAK-715 distributor | TAK-715 structure buy 303162-79-0 | 303162-79-0 Supplier | purchase 303162-79-0 | 303162-79-0 cost | 303162-79-0 manufacturer | order 303162-79-0 | 303162-79-0 distributor | 303162-79-0 structure