Network Version
Tubulysin A Data Sheet
| Product Name: | Tubulysin A |
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|---|---|---|
| CAS No.: | 205304-86-5 | |
| Cat. No.: | HY-15995 | |
| MWt: | 844.07 | |
| Formula: | C43H65N5O10S | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin< b>ADC Cytotoxin[1][2][3][4].
In Vitro:The IC50 values of Tubulysin A in the NCI-H1299 (lung), HT-29 (colon) and A2780 (ovary) cell lines are 3, 1 and 2 nmol/L, respectively[4]. The IC50 values of Tubulysin A against L929 (mouse fibroblast) and KB-V1 (human cervical cancer multidrug resistant cell line) cells were 0.07 and 1.4 ng/ml, respectively[1]. Tubulysin A (1 nM, 10 nM; 24h) has an antiangiogenic effect in HUVEC cells with IC50 values of 2.07-2.97 nM[1]. Tubulysin A (5h) can inhibit cell migration in HUVEC cells with IC50 value of 2.26 nM[1]. Tubulysin A (72h) can inhibit cell growth in HUVEC cells with GI50 value of 0.34 nM[1]. In Vivo:Tubulysin A (0.04 mg/kg, 0.06 mg/kg; Intraperitoneal (i.p.); once daily for 4 days) can inhibit the growth of tumor cells in mouse xenotransplantation model[1]. |
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