Network Version
Wnt-C59 Data Sheet
| Product Name: | Wnt-C59 |
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| CAS No.: | 1243243-89-1 | |
| Cat. No.: | HY-15659 | |
| MWt: | 379.45 | |
| Formula: | C25H21N3O | |
| Purity : | >98% | |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Cancer Cardiovascular Disease Inflammation/Immunology Neurological Disease | |
| Biological Activity: | ||
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Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
IC50 & Target:IC50: 74 pM (PORCN)[1]
In Vitro: Wnt-C59 (C59) inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity. Wnt-C59 inhibits WNT3A-mediated activation of a multimerized TCF-binding site driving luciferase with an IC50 of 74 pM[1].
In Vivo: Wnt-C59 displays good bioavailability in mice. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes[1]. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors. Wnt-C59 inhibits stemness properties of NPC cells in a dosage-dependent manner by arresting sphere formation in both HNE1 and SUNE1 cells[2]. |
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