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YK-4-279 Data Sheet

Product Name: YK-4-279
CAS No.: 1037184-44-3
Cat. No.: HY-14507
MWt: 366.2
Formula: C17H13Cl2NO4
Purity : >98%
Solubility: DMSO : 25 mg/mL (ultrasonic)
Mechanisms: Target: Cancer
Biological Activity:
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer[1][2]. IC50 & Target: IC50: 0.94 µM (TC32), 1.83 µM (TC71), 1.03 µM (RDES), 0.33 µM (SKES), 0.94 µM (MMH-ES-1), 0.60 µM (STA-ET 7.2), 1.46 µM (A4573), 4.95 µM (PC3), 22.82 µM ( MCF7), 0.82 µM (MDA-MB-231), 1.514 µM (PANC1), 14.28 µM (ASPC1)[2] In Vitro: YK-4-279 (3-30 µM; overight) dissociates EWS-FLI1 from RHA in Ewing’s sarcoma family tumor (ESFT) cells[1].
YK-4-279 (3-30 µM; 14 h) nearly eliminates cyclin D1 in TC32 cells[1].
YK-4-279 (3-30 µM; 72 h) potently and specifically inhibits ESFTs[1].
YK-4-279 (50 µM; 6 h) induces substantial apoptosis of ESFT cells[1].
YK-4-279 (0.1-30 µM; 72 h) inhibits the growth of ESFT, prostate, breast and pancreatic cancer cells[2]. In Vivo: YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth[1].

Caution: Not fully tested. For research purposes only

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