Network Version
Product Name: | AR-C155858 | |
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CAS No.: | 496791-37-8 | |
Cat. No.: | HY-13248 | |
MWt: | 461.53 | |
Formula: | C21H27N5O5S | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 50 mg/mL (108.34 mM) | |
Mechanisms: | Target: Others | |
Biological Activity: | ||
AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively. IC50 & Target: Ki: 2.3 nM (MCT1), 10 nM (MCT2) In Vitro: AR-C155858 (10 nM-100 nM) inhibits MCT1/MCT2 C-terminal chimaeras[1]. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner[2]. |
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