Network Version
Balofloxacin Data Sheet
| Product Name: | Balofloxacin |
 |
|---|---|---|
| CAS No.: | 127294-70-6 | |
| Cat. No.: | HY-B0159 | |
| MWt: | 389.42 | |
| Formula: | C20H24FN3O4 | |
| Purity : | >98% | |
| Solubility: | DMSO : 0.67 mg/mL (ultrasonic);H<sub>2</sub>O : < 0.1 mg/mL | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
|
Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections[1][2].
In Vitro: Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs)[2]. Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL[2]. Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL[2]. In Vivo: Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters[3]. Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits[2]. |
||
1 Deer Park Dr, Suite F, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com