Network Version
Balofloxacin Data Sheet
| Product Name: | Balofloxacin |
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| CAS No.: | 127294-70-6 | |
| Cat. No.: | HY-B0159 | |
| MWt: | 389.42 | |
| Formula: | C20H24FN3O4 | |
| Purity : | >98% | |
| Solubility: | DMSO : 0.67 mg/mL (1.72 mM; Need ultrasonic); H2O : 0.67 mg/mL (1.72 mM; Need ultrasonic) | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
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Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections[1][2].
In Vitro: Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs)[2]. Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL[2]. Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL[2]. In Vivo: Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters[3]. Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits[2]. |
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