Network Version
Product Name: | Cephalomannine | |
---|---|---|
CAS No.: | 71610-00-9 | |
Cat. No.: | HY-77554 | |
MWt: | 831.9 | |
Formula: | C45H53NO14 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 100 mg/mL | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
Cephalomannine is a Paclitaxel (HY-B0015) alkaloidal analog that can be isolated from most Cephalotaxus species. Cephalomannine is an orally active anti-tumor agent and can be used as a chemotherapy agent for cancer research[1][2][3][4].
In Vitro:Cephalomannine significantly inhibits the proliferation of H460, A549 and H1299 cells under normal oxygen conditions, with IC50 values of 0.18, 0.20 and 0.37 μM, respectively. Cephalomannine shows obvious inhibitory effect on cell viability under hypoxia[3]. Cephalomannine (0, 0.025, 0.05, 0.1 μM; 0, 12, 24h) inhibiting the interaction of APEX1/HIF-1α can also significantly inhibit the cell viability, ROS production, intracellular pH, migration of hypoxic lung cancer cells, and angiogenesis of hypoxic human umbilical vein endothelial cells (HUVECs)[3]. Cephalomannine dose-dependently inhibits UBE2S expression and thus suppresses prostate cancer (PCa) growth and metastasis[4]. In Vivo:Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects[3]. Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1[3]. |
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com
Keywords: buy Cephalomannine | Cephalomannine Supplier | purchase Cephalomannine | Cephalomannine cost | Cephalomannine manufacturer | order Cephalomannine | Cephalomannine distributor | Cephalomannine structure buy 71610-00-9 | 71610-00-9 Supplier | purchase 71610-00-9 | 71610-00-9 cost | 71610-00-9 manufacturer | order 71610-00-9 | 71610-00-9 distributor | 71610-00-9 structure