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Fosbretabulin disodium Data Sheet
| Product Name: | Fosbretabulin disodium |
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|---|---|---|
| CAS No.: | 168555-66-6 | |
| Cat. No.: | HY-17449 | |
| MWt: | 440.29 | |
| Formula: | C18H19Na2O8P | |
| Purity : | >98% | |
| Solubility: | DMSO : < 1 mg/mL (insoluble or slightly soluble); H2O : 4.5 mg/mL (10.22 mM; Need ultrasonic and warming); DMF : 1 mg/mL (2.27 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3]. IC50 & Target: tubulin[1] In Vitro: Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively[2]. In Vivo: Fosbretabulin disodium (100 mg/kg; i.p.) increases the mean arterial blood pressure (MABP) at 1 and 6 h after administration and decreases the tumor blood flow in rats[3]. | ||
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