Network Version
JNK-IN-7 Data Sheet
| Product Name: | JNK-IN-7 |
 |
|---|---|---|
| CAS No.: | 1408064-71-0 | |
| Cat. No.: | HY-15617 | |
| MWt: | 493.56 | |
| Formula: | C28H27N7O2 | |
| Purity : | >98% | |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H<sub>2</sub>O : < 0.1 mg/mL | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. IC50 & Target: IC50: 1.5 nM (JNK1), 2 nM (JNK2), 0.7 nM (JNK3)[1] In Vitro: JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C[1]. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function[2]. | ||
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] Web:www.medchemexpress.com