Network Version
PSI-7976 Data Sheet
| Product Name: | PSI-7976 |
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|---|---|---|
| CAS No.: | 1190308-01-0 | |
| Cat. No.: | HY-15005A | |
| MWt: | 529.45 | |
| Formula: | C22H29FN3O9P | |
| Purity : | >98% | |
| Solubility: | 10 mM in DMSO | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
| PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. In Vitro: PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 being the more active inhibitor of HCV RNA replication in the HCV replicon assay. Carboxylesterase 1 (CES1) preferentially hydrolyzes PSI-7976 over PSI-7977. The kinetic data also indicates that PSI-7976 is a better substrate for CES1 than for cathepsin A (CatA)[1] | ||
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