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Decoyinine  (Synonyms: Angustmycin A)

製品番号: HY-101835 純度: 99.96%
COA 取扱説明書

Decoyinine is a selective inhibitor of GMP synthetase (GMPS).

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Decoyinine 構造式

Decoyinine 構造式

CAS 番号 : 2004-04-8

容量 価格(税別) 在庫状況 数量
Solution
10 mM * 1 mL in DMSO USD 614 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 614 在庫あり
Estimated Time of Arrival: December 31
Solid
1 mg USD 200 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 800 在庫あり
Estimated Time of Arrival: December 31
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Decoyinine is a selective inhibitor of GMP synthetase (GMPS).

IC50 & Target

GMPS[1].

体外実験

Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the gra-10 mutation. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. It is observed that purine nucleotides, most notably GMP, exhibits a dramatic inhibitory effect on the activity of Bacillus circulans F-2 amylase and a less-pronounced inhibitory effect on B. subtilis aamylase. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on B. subtilis WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

It is showed that Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Moreover, like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

279.25

分子式

C11H13N5O4

CAS 番号
SMILES

C=C(O1)[[email protected]@H](O)[[email protected]@H](O)[[email protected]]1(CO)N2C=NC3=C(N)N=CN=C32

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (179.05 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5810 mL 17.9051 mL 35.8102 mL
5 mM 0.7162 mL 3.5810 mL 7.1620 mL
10 mM 0.3581 mL 1.7905 mL 3.5810 mL
*Please refer to the solubility information to select the appropriate solvent.
純度とドキュメンテーション

純度: 99.96%

参考文献
細胞実験
[2]

The isogenic strains WLN-4 (sacA321 amyRJ-amyE+) and WLN-11 (sacA321 gra-10-amyE+) are inoculated into minimal S7 medium, containing 2% (wt/vol) glucose, from washed exponential-phase seed cultures grown in the same medium. At mid-logarithmic growth phase, each culture is evenly subdivided into two flasks containing either 1/10 the culture volume of fresh S7 medium or a 1/10 volume of filter-sterilized S7 medium to which 2.5 mg of Decoyinine per ml has previously been dissolved (final Decoyinine concentration, 250 μg/mL). At regular intervals before and after the decoyinine addition, samples are removed from the cultures and the culture supernatants are assayed for a-amylase as described previously. At 16 h after the Decoyinine addition, the frequency of heatresistant spores in each culture is determined[2].

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

動物実験
[1]

Mice[1]
SK-Mel-103 and SK-Mel-28 cells are inoculated subcutaneously in both flanks of SCID mice (18 mice/cell line). Once tumors volume reach approximately 100 mm3, mice are randomly assigned to one of four groups and treated with daily i.p. injections of Decoyinine (120 mg/kg), MMF (30 mg/kg), or with respective vehicles. Tumor size is measured every other day with a caliper and mice are killed once tumor volume reach 1000 mm3 or the animals show signs of morbidity[1].

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Decoyinine
製品番号:
HY-101835
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