1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Dihydroisotanshinone I

Dihydroisotanshinone I 

Cat. No.: HY-B1919 Purity: 99.52%
Handling Instructions

Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.

For research use only. We do not sell to patients.

Dihydroisotanshinone I Chemical Structure

Dihydroisotanshinone I Chemical Structure

CAS No. : 20958-18-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 238 Get quote
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
25 mg USD 696 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1176 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.

IC50 & Target[1]



In Vitro

Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1[1]. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently[2].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)

H2O : < 0.1 mg/mL (insoluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

Dihydroisotanshinone I is dissolved in ethyl acetate and mixed with the culture medium. The final concentration of ethyl acetate is 0.1% (v/v). Cell are treated with 2.5, 5, 10, and 20 μM dihydroisotanshinone I for 24 hours. The cell viability is measured using the MTT assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.52%

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Dihydroisotanshinone ISTATInhibitorinhibitorinhibit

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