2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG2-C4-Cl

(S,R,S)-AHPC-PEG2-C4-Cl  (Synonyms: VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10)

Cat. No.: HY-103607 Purity: 98.21%
COA Handling Instructions

Molarity Calculator

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-C4-Cl Chemical Structure

(S,R,S)-AHPC-PEG2-C4-Cl Chemical Structure

CAS No. : 1835705-57-1

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100 mg USD 550 In-stock
500 mg USD 1950 In-stock
1 g USD 3350 In-stock
2 g USD 4900 In-stock
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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG2-C4-Cl Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

IC50 & Target[1]

VHL

 

In Vitro

(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand[1]. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG2-C4-Cl Related Antibodies
Molecular Weight

651.26

Formula

C32H47ClN4O6S
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (76.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (76.77 mM; Need ultrasonic)

Ethanol : 50 mg/mL (76.77 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5355 mL 7.6774 mL 15.3548 mL
5 mM 0.3071 mL 1.5355 mL 3.0710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.21%

COA (249 KB) HNMR (306 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / Ethanol 1 mM 1.5355 mL 7.6774 mL 15.3549 mL 38.3871 mL
5 mM 0.3071 mL 1.5355 mL 3.0710 mL 7.6774 mL
10 mM 0.1535 mL 0.7677 mL 1.5355 mL 3.8387 mL
15 mM 0.1024 mL 0.5118 mL 1.0237 mL 2.5591 mL
20 mM 0.0768 mL 0.3839 mL 0.7677 mL 1.9194 mL
25 mM 0.0614 mL 0.3071 mL 0.6142 mL 1.5355 mL
30 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2796 mL
40 mM 0.0384 mL 0.1919 mL 0.3839 mL 0.9597 mL
50 mM 0.0307 mL 0.1535 mL 0.3071 mL 0.7677 mL
60 mM 0.0256 mL 0.1280 mL 0.2559 mL 0.6398 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-PEG2-C4-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-C4-Cl1835705-57-1VH032-PEG2-C4-Cl VHL Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 10E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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