1. Anti-infection
    Cell Cycle/DNA Damage
    Autophagy
  2. Parasite
    DNA/RNA Synthesis
    Autophagy
    Bacterial
    Antibiotic
  3. Emetine dihydrochloride hydrate

Emetine dihydrochloride hydrate 

Cat. No.: HY-B1479B Purity: 99.81%
Handling Instructions

Emetine dihydrochloride hydrate, derived from the ipecac root, is a potent anti-protozoal and emetic agent. Emetine dihydrochloride hydrate inhibits viral polymerases and inhibits Zika and Ebola virus infections. Emetine dihydrochloride hydrate potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect.

For research use only. We do not sell to patients.

Emetine dihydrochloride hydrate Chemical Structure

Emetine dihydrochloride hydrate Chemical Structure

CAS No. : 7083-71-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Emetine dihydrochloride hydrate, derived from the ipecac root, is a potent anti-protozoal and emetic agent. Emetine dihydrochloride hydrate inhibits viral polymerases and inhibits Zika and Ebola virus infections. Emetine dihydrochloride hydrate potently inhibits autophagy and has anti-malarial, anti-bacterial and anti-amoebic effect[1][2][3][4].

In Vitro

Emetine dihydrochloride hydrate accumulates SQSTM1 and MAP1LC3B in SNB-19 cells, indicating autophagy is blocked[1].
Emetine dihydrochloride hydrate dose-dependently decreases NS1 protein level in HEK293 cells infected with the African prototype, ZIKV MR766 (IC50=52.9 nM). Emetine dihydrochloride directly inhibits ZIKV NS5 RNA polymerase activity with an IC50 of 121 nM[1].

Cell Autophagy Assay[1]

Cell Line: SNB-19 cells
Concentration: 25, 50, 100, 200 nM
Incubation Time: For 24 hours
Result: Showed the accumulation of SQSTM1 and MAP1LC3B, indicating autophagy was blocked.
In Vivo

Emetine dihydrochloride hydrate (1, 2 mg/kg/day; IP; for 3 days) significantly reduces the serum viral load of ZIKV infected Ifnar1−/− mice[1].
Emetine dihydrochloride hydrate (1 mg/kg/day; retro-orbital injection; for six days) reduces the levels of circulating ZIKV approximately 10-fold in three-month-old female SJL mice with ZIKVBR[1].
Emetine (0.002, 0.02, 0.2, 2 mg/kg/day; i.p.) not only attenuates blood glucose levels in dose-dependent way but also induces a persistent attenuation of blood glucose levels in C57Bl/6 male mice (20-25 g)[2].

Animal Model: Ifnar1−/− mice[1]
Dosage: 1, 2 mg/kg
Administration: IP; once daily for 3 days
Result: Significantly reduced the serum viral load of ZIKV infected Ifnar1−/− mice.
Molecular Weight

571.58

Formula

C₂₉H₄₀N₂O₄ . ₂ HCl . H₂O

CAS No.

7083-71-8

SMILES

CC[[email protected]@H]1[[email protected]](C[[email protected]@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C1)C[[email protected]]4([H])C5=CC(OC)=C(OC)C=C5CCN4.[H]Cl.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.5 mg/mL (28.87 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7495 mL 8.7477 mL 17.4954 mL
5 mM 0.3499 mL 1.7495 mL 3.4991 mL
10 mM 0.1750 mL 0.8748 mL 1.7495 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.81%

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Keywords:

Emetine dihydrochlorideParasiteDNA/RNA SynthesisAutophagyBacterialAntibioticipecacrootanti-protozoalemeticviralpolymerasesZikaEbolaanti-malarialInhibitorinhibitorinhibit

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Emetine dihydrochloride hydrate
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