1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. FT671

FT671 

Cat. No.: HY-107985
Handling Instructions

FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM.

For research use only. We do not sell to patients.

FT671 Chemical Structure

FT671 Chemical Structure

CAS No. : 1959551-26-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 2934 In-stock
Estimated Time of Arrival: December 31
1 mg USD 800 In-stock
Estimated Time of Arrival: December 31
5 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM.

IC50 & Target

IC50: 52 nM (USP7)[1]

Kd: 65 nM (USP7)[1]

In Vitro

FT671 increases p53 protein levels in HCT116 or bone osteosarcoma (U2OS) cell lines, leading to induction of p53 target genes including BBC3 (which encodes PUMA), CDKN1A (p21), RPS27L (S27L) and MDM2. FT671 leads to the degradation of N-Myc and upregulation of p53 in the neuroblastoma cell line IMR-32. FT671 also stabilizes p53 in the MM.1S multiple myeloma cell line, which correlates with increased MDM2 ubiquitination and leads to expression of p53 target genes[1].

In Vivo

FT671 (100 mg/kg and 200 mg/kg, Oral gavage, daily) treatment in mice leads to a significant dose-dependent inhibition of tumor growth. And FT671 is well-torelated even at high doses[1].

Animal Model: Non-obese diabetic-severe combined immunodeficient (NOD–SCID) mice implanted with MM.1S cells[1].
Dosage: 100 mg/kg and 200 mg/kg.
Administration: Oral gavage daily.
Result: Led to a significant dose-dependent inhibition of tumor growth.
Molecular Weight

533.48

Formula

C₂₄H₂₃F₄N₇O₃

CAS No.

1959551-26-8

SMILES

FC1=CC=C(N2N=CC3=C2N=CN(CC4(O)CCN(C(C[[email protected]@H](C(F)F)N5N=C(F)C=C5)=O)CC4)C3=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FT671FT 671FT-671DeubiquitinaseDUBsInhibitorinhibitorinhibit

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FT671
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HY-107985
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