1. Anti-infection
  2. Bacterial
  3. Gatifloxacin hydrochloride

Gatifloxacin hydrochloride (Synonyms: AM 1155 hydrochloride; BMS 206584-01 hydrochloride; PD 135432 hydrochloride)

Cat. No.: HY-10581A
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Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

For research use only. We do not sell to patients.

Gatifloxacin hydrochloride Chemical Structure

Gatifloxacin hydrochloride Chemical Structure

CAS No. : 121577-32-0

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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Target: Antibacterial Gatifloxacin (hydrochloride) is the hydrochloride salt of Gatifloxacin which is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Gatifloxacin had activity equal to that of tosufloxacin and activity more potent than those of norfloxacin, ofloxacin, ciprofloxacin, and sparfloxacin against the second-step mutants (grlA gyrA; gatifloxacin MIC range, 1.56 to 3.13 microg/ml) and had the most potent activity against the third-step mutants (grlA gyrA grlA; gatifloxacin MIC range, 1.56 to 6.25 microg/ml), suggesting that gatifloxacin possesses the most potent inhibitory activity against singly mutated topo IV and singly mutated DNA gyrase among the quinolones tested [1]. Ophthalmic gatifloxacin 0.3% is at least as effective as ciprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than ciprofloxacin. Trends favored gatifloxacin in fluorescein retention scores [2]. Clinical indications: Bacterial infection FDA Approved Date: Toxicity: Hepatotoxicity; Acute pancreatitis [3]; Torsades de pointes [4]

Clinical Trial
Molecular Weight

411.86

Formula

C₁₉H₂₃ClFN₃O₄

CAS No.

121577-32-0

SMILES

CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GatifloxacinAM 1155BMS 206584-01PD 135432AM1155AM-1155PD135432PD-135432BacterialInhibitorinhibitorinhibit

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Gatifloxacin hydrochloride
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HY-10581A
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