1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. Cathepsin Inhibitor 2

Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.

For research use only. We do not sell to patients.

Cathepsin Inhibitor 2 Chemical Structure

Cathepsin Inhibitor 2 Chemical Structure

CAS No. : 1017931-53-1

Size Price Stock Quantity
1 mg USD 426 In-stock
5 mg USD 939 In-stock
10 mg USD 1500 In-stock
25 mg USD 3156 In-stock
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Description

Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.

IC50 & Target

Ki: <20 nM (Cathepsin S)[1]

In Vitro

Cathepsin Inhibitor 2 (Please refer to paragraph 0229 for detailed information) potently inhibits Cathepsin S, Cathepsin F, Cathepsin L, and Cathepsin B with Kis of <20 nM, 21-500 nM, 21-500 nM, and 21-500 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.38

Formula

C19H21F6N3O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)[C@H](C1=CC=C(F)C=C1)N[C@@H](CC(F)(F)CCC)C(NC2(CC2)C#N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3732 mL 11.8658 mL 23.7315 mL
5 mM 0.4746 mL 2.3732 mL 4.7463 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3732 mL 11.8658 mL 23.7315 mL 59.3289 mL
5 mM 0.4746 mL 2.3732 mL 4.7463 mL 11.8658 mL
10 mM 0.2373 mL 1.1866 mL 2.3732 mL 5.9329 mL
15 mM 0.1582 mL 0.7911 mL 1.5821 mL 3.9553 mL
20 mM 0.1187 mL 0.5933 mL 1.1866 mL 2.9664 mL
25 mM 0.0949 mL 0.4746 mL 0.9493 mL 2.3732 mL
30 mM 0.0791 mL 0.3955 mL 0.7911 mL 1.9776 mL
40 mM 0.0593 mL 0.2966 mL 0.5933 mL 1.4832 mL
50 mM 0.0475 mL 0.2373 mL 0.4746 mL 1.1866 mL
60 mM 0.0396 mL 0.1978 mL 0.3955 mL 0.9888 mL
80 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7416 mL
100 mM 0.0237 mL 0.1187 mL 0.2373 mL 0.5933 mL
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Cathepsin Inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cathepsin Inhibitor 2
Cat. No.:
HY-U00377
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