1. GPCR/G Protein
  2. Leukotriene Receptor

Iralukast (Synonyms: CGP 45715A)

Cat. No.: HY-101944
Handling Instructions

Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

For research use only. We do not sell to patients.

Iralukast Chemical Structure

Iralukast Chemical Structure

CAS No. : 151581-24-7

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  • Biological Activity

  • Technical Information

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  • References

Description

Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

IC50 & Target[1]

CysLT1

7.8 (pKi)

In Vitro

Both Iralukast and CGP 57698 are able to compete for the two sites labelled by [3H]-LTD4. As in all the G-protein coupled receptors, Iralukast and CGP 57698 do not discriminate between the high and the low affinitystates of the CysLT receptor labelled by LTD4 (Ki1=Ki2=16.6 nM±36% CV and Ki1=Ki2=5.7 nM±19% CV, respectively). Iralukast, displays a slow bindingkinetic, because preincubation (15 min) increases its antagonist potency. Iralukast and CGP 57698 antagonize LTD4-induced contraction of humanbronchi, with pA2 values of 7.77±4.3% CV and 8.51±1.6% CV, respectively, and slopes not significantly different from unity[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4069 mL 7.0347 mL 14.0694 mL
5 mM 0.2814 mL 1.4069 mL 2.8139 mL
10 mM 0.1407 mL 0.7035 mL 1.4069 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

710.76

Formula

C₃₈H₃₇F₃O₈S

CAS No.

151581-24-7

SMILES

O=C(C1=CC(C2=CC=C(S[[email protected]]([[email protected]](O)C3=CC=CC(C(F)(F)F)=C3)/C=C/C=C\CCCCOC4=CC=C(C(C)=O)C(O)=C4CCC)C=C2O1)=O)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Iralukast
Cat. No.:
HY-101944
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Iralukast

Cat. No.: HY-101944