1. IRAK
  2. JH-X-119-01 hydrochloride

JH-X-119-01 hydrochloride 

Cat. No.: HY-103017 Purity: >98.0%
Handling Instructions

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice.

For research use only. We do not sell to patients.

JH-X-119-01 hydrochloride Chemical Structure

JH-X-119-01 hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 520 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice[1].

IC50 & Target[1]

IRAK1

 

In Vitro

Jh-X-119-01 (10 μM) decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. Jh-X-119-01 selectively inhibits IRAK1 phosphorylation[1].

Western Blot Analysis[1]

Cell Line: RAW 264.7 cells and THP-1 cells
Concentration: 10 μM
Incubation Time: 15 minutes
Result: Decreased LPS (100 ng/mL)-induced phosphorylation of IκBα and NF-κB-P65.
In Vivo

Jh-X-119-01 improves survival and decreases immunopathies of LPS-challenged mice. Jh-X-119-01 increases survival of mice at the dose of 5 mg/kg body weight. Survival is further improved when the dose is increased to 10 mg/kg[1].

Animal Model: C57BL/6 (20-22 g, male) mice[1]
Dosage: 5 mg/kg and 10 mg/kg
Administration: Intraperitoneally injected; 5 days
Result: Protected mice from LPS (20 mg/kg)-induced sepsis. Survival at day 5 was 13.3% in control group where septic mice were treated by vehicle, while the values were 37.5% and 56.3% for 5 mg/kg and 10 mg/kg.
Molecular Weight

488.93

Formula

C₂₅H₂₁ClN₆O₃

SMILES

O=C(C=C)NC1=CC=CC(C(NC2=CC=C(NC(C3=NC(C4=CC=NN4)=CC=C3)=O)C=C2)=O)=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.26 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0453 mL 10.2264 mL 20.4528 mL
5 mM 0.4091 mL 2.0453 mL 4.0906 mL
10 mM 0.2045 mL 1.0226 mL 2.0453 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.11 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

JH-X-119-01IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK1,SepsisLipopolysaccharideMacrophageInhibitorinhibitorinhibit

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Product Name:
JH-X-119-01 hydrochloride
Cat. No.:
HY-103017
Quantity:
MCE Japan Authorized Agent: