Kresoxim-methyl  (Synonyms: BAS 490 F)

Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K_d of 0.07 μM proving a high affinity for this enzyme^[1][2].

Kresoxim-methyl affects antioxidant response, mitochondrial function and motility of neuroblastoma N2a cells upon 24h exposure^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

313.35

C₁₈H₁₉NO₄

143390-89-0

Liquid

Colorless to light yellow

O=C(OC)/C(C1=CC=CC=C1COC2=CC=CC=C2C)=N/OC

Room temperature in continental US; may vary elsewhere.

• [1]. Roehl F. Binding of BAS 490 F to bc1-complex from yeast. Biochem Soc Trans. 1994;22(1):64S.  [Content Brief]

  [2]. Köhle H, et al. Biokinetic properties of BAS 490 F and some related compounds. Biochem Soc Trans. 1994;22(1):65S.  [Content Brief]

  [3]. Flampouri E, et al. Strobilurin fungicide kresoxim-methyl effects on a cancerous neural cell line: oxidant/antioxidant responses and in vitro migration. Toxicol Mech Methods. 2018;28(9):709-716.  [Content Brief]