1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Endogenous Metabolite
  3. L-Epinephrine

L-Epinephrine (Synonyms: (-)-Epinephrine; L-Adrenaline; (-)-Adrenalin)

Cat. No.: HY-B0447B Purity: >99.0%
Handling Instructions

L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

For research use only. We do not sell to patients.

L-Epinephrine Chemical Structure

L-Epinephrine Chemical Structure

CAS No. : 51-43-4

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Estimated Time of Arrival: December 31

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Based on 4 publication(s) in Google Scholar

Other Forms of L-Epinephrine:

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L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

IC50 & Target

Human Endogenous Metabolite


In Vivo

A 25 microliter volume of a 1-% L-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes[1]. Epinephrine is a direct-acting sympathomimetic α-adrenergic and β-adrenergic agonist with cyclic adenosine monophosphate-mediated, complex, bidirectional pharmacologic effects on many target organs[2]. In young adult rats, endogenous release of epinephrine facilitates stable memory formation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[3]. Epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increases arterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects[4].

Clinical Trial
Molecular Weight







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Room temperature in continental US; may vary elsewhere.


4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 2.22 mg/mL (12.12 mM; Need ultrasonic)

H2O : 2 mg/mL (10.92 mM; ultrasonic and adjust pH to 2 with HCl)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4585 mL 27.2926 mL 54.5852 mL
5 mM 1.0917 mL 5.4585 mL 10.9170 mL
10 mM 0.5459 mL 2.7293 mL 5.4585 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Rats: For the immunohistochemistry experiments, rats receive an immediate post-training subcutaneous injection of saline (0.9%), glucose (250 mg/kg), or epinephrine (0.1 mg/kg) and are then returned to the holding cage[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: >99.0%

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L-Epinephrine(-)-EpinephrineL-Adrenaline(-)-AdrenalinAdrenergic ReceptorEndogenous MetaboliteBeta ReceptorInhibitorinhibitorinhibit

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